Pet serine protease from enteroaggregative Escherichia coli stimulates the inflammatory response activating human macrophages
نویسندگان
چکیده
منابع مشابه
Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coli.
We have previously described enteroaggregative Escherichia coli (EAEC) strains that induce cytotoxic effects on T84 cells, ligated rat ileal loops, and human intestine in culture. Such strains secrete a 104-kDa protein termed Pet (for plasmid-encoded toxin). We have also shown previously that the Pet toxin induces rises in short-circuit current and decreases the electrical resistance in rat jej...
متن کاملThe serine protease motif of EspC from enteropathogenic Escherichia coli produces epithelial damage by a mechanism different from that of Pet toxin from enteroaggregative E. coli.
EspC (Escherichia coli secreted protein C) of enteropathogenic E. coli (EPEC) shows the three classical domains of the autotransporter proteins and has a conserved serine protease motif belonging to the SPATE (serine protease autotransporters of Enterobacteriaceae) subfamily. EspC and its homolog Pet in enteroaggregative E. coli (EAEC) bear the same sequence within the serine protease motif, an...
متن کاملPet, an autotransporter enterotoxin from enteroaggregative Escherichia coli.
Enteroaggregative Escherichia coli (EAEC) is an emerging cause of diarrheal illness. Clinical data suggest that diarrhea caused by EAEC is predominantly secretory in nature, but the responsible enterotoxin has not been described. Work from our laboratories has implicated a ca. 108-kDa protein as a heat-labile enterotoxin and cytotoxin, as evidenced by rises in short-circuit current and falls in...
متن کاملEnteroaggregative Escherichia coli.
Enteroaggregative Escherichia coli (EAEC) are an increasingly important cause of diarrhoea. E. coli belonging to this category cause watery diarrhoea, which is often persistent and can be inflammatory. EAEC have been implicated in sporadic diarrhoea in children and adults, in both developing and developed countries, and have been identified as the cause of several outbreaks worldwide. EAEC are ...
متن کاملPlasmid encoded enterotoxin (Pet) gene in enteroaggregative Escherichia coli isolated from sporadic diarrhea cases.
(2). The aggregative adherence of EAggEC was due to the presence of aggregative adherence fimbriae (AAF), AAF/ 1 and AAF/lI, whose expression lS positively controlled by the aggR gene (2)・ This aggR gene is present in many EAggECs, but some aggR-positive E. coli isolates have no AAFs (3,4). EAggEC was found to produce EAggEC heat-stable enterotoxin (EASTl encoded by astA, molecular weight 4.1 k...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2016
ISSN: 1471-2180
DOI: 10.1186/s12866-016-0775-7